Alpha7 Nicotinic Acetylcholine Receptor Down Regulation Impairs Mitochondrial Function in Streptozotocin-induced Sporadic Alzheimer's Disease Model in Rats

Abstract: Background/Aim: Alzheimer’s disease (AD), a type of neurodegenerative disorder, possesses significant memory loss as one the cardinal manifestations. The pathophysiology AD includes increased accumulation A?, degeneration cholinergic activity and mitochondrial dysfunction. Nicotinic acetylcholine receptors (nAChRs) especially alpha7 nicotinic (?7 nAChRs) are widely distributed in brain associated with function. Further, we explored correlation between dysfunction expression level ?7 nAChRs STZ challenged regions rats. Materials Methods: group rats received intracerebroventricular infusion (3 mg/kg) on D-1 D-3 experimental design 18 days. Behavioral parameters ware investigated using MWM Y-maze test paradigm. biochemical analysis was assessed all three Results: administration caused impairment learning There decrease functions terms elevated AChE decreased ACh ChAT rat hippocampus, pre-frontal cortex amygdala. significantly attenuated function, integrity bioenergetics selected regions. Interestingly, A? Conclusion: nAChR down regulation may form basis to cognitive deficits along dysfunction, sensitive Thus, could be an alternative potential target management AD. Key words: disease, Streptozotocin, nAChR, Mitochondria, Acetylcholine, Hippocampus.